cd39 | ENTPD1 - Wikipedia

Keyword	CPC	PCC	Volume	Score	Length of keyword
cd39	0.26	0.9	6427	93	4

Keyword	CPC	PCC	Volume	Score
cd39	1.72	1	1938	11
cd39 gene	0.07	0.4	9493	23
cd39 cd73	1.54	0.3	1340	56
cd39 marker	1.83	0.1	126	8
cd39 treg	1.56	0.2	2979	19
cd39 t cell	1.57	0.1	9137	14
cd39 antibody	1.63	0.3	4784	25
cd39+	1.92	0.5	3055	8
cd39petanque	0.05	0.1	8658	93
cd39 inhibitor	0.27	0.9	7390	2
cd39 cd103	1.63	0.1	7458	99
cd39 t cell marker	1.51	0.2	3302	31

Search Results related to cd39 on Search Engine

ENTPD1 - Wikipedia
wikipedia.org

https://en.wikipedia.org/wiki/ENTPD1

WEBCD39 converts ATP (or ADP) to adenosine monophosphate (AMP), which is converted into adenosine by CD73. A substantial portion of the immune suppressive and anti-inflammatory activity of regulatory T cells (Tregs) is due to the adenosine produced by the CD39/CD73 pathway, insofar as Tregs express CD39 and CD73.

DA: 61 PA: 44 MOZ Rank: 57

Targeting CD39 in cancer | Nature Reviews Immunology
nature.com

https://www.nature.com/articles/s41577-020-0376-4

WEBJul 29, 2020 · Here, we review what is known about the effect of CD39 and eATP on various cell types (Table 1) and immune processes, and discuss its potential as a new target in cancer. Table 1 Effects of...

DA: 26 PA: 34 MOZ Rank: 92

CD39 Regulation and Functions in T Cells - PMC - National …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348030/

WEBJul 28, 2021 · CD39 is an enzyme which is responsible, together with CD73, for a cascade converting adenosine triphosphate into adenosine diphosphate and cyclic adenosine monophosphate, ultimately leading to the release of an immunosuppressive form of adenosine in the tumor microenvironment.

DA: 5 PA: 38 MOZ Rank: 32

Review immune response of targeting CD39 in cancer
biomedcentral.com

https://biomarkerres.biomedcentral.com/articles/10.1186/s40364-023-00500-w

WEBJun 7, 2023 · Targeting CD39 in cancer has been shown to not only decrease adenosine levels in the tumor microenvironment (TME), but also increase ATP levels. Additionally, targeting CD39 can limit the function of Treg cells, which are known to …

DA: 89 PA: 95 MOZ Rank: 44

CD39 and CD73 in immunity and inflammation - PMC - National …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674206/

WEBCD39 and CD73 shape the “purinergic halo” surrounding immune cells. The occurrence of pathological events, such as inflammation, promotes a massive accumulation of ATP, which serves as a key “danger” signal, triggering a series of proinflammatory responses (a).

DA: 76 PA: 69 MOZ Rank: 28

Human soluble CD39 displays substrate inhibition in a substrate
nature.com

https://www.nature.com/articles/s41598-023-36257-3

WEBJun 2, 2023 · CD39 (ectonucleoside triphosphate diphosphohydrolase-1; ENTPD1) metabolizes extracellular ATP and ADP to AMP. AMP is subsequently metabolized by CD79 to adenosine. CD39 activity is therefore a...

DA: 98 PA: 89 MOZ Rank: 16

Cancer CD39 drives metabolic adaption and mal-differentiation of …
nature.com

https://www.nature.com/articles/s41419-023-06336-4

WEBDec 8, 2023 · Cancer CD39 drives metabolic adaption and mal-differentiation of CD4+ T cells in patients with non-small-cell lung cancer | Cell Death & Disease. Article. Open access. Published: 08 December...

DA: 58 PA: 75 MOZ Rank: 3

CD39 – A bright target for cancer immunotherapy - ScienceDirect
sciencedirect.com

https://www.sciencedirect.com/science/article/pii/S0753332222004553

WEBJul 1, 2022 · CD39 inhibitors or anti-CD39 antibodies have shown theoretical potential as novel drugs for cancer immunotherapy in a twofold fashion attributed to its ability to enhance intratumor immunostimulatory eATP concentration and reduce the generation of AMP, which can be further hydrolyzed by CD73 to immunosuppressive, cancer-promoting eADO.

DA: 69 PA: 67 MOZ Rank: 98

CD39 and control of cellular immune responses - PMC
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2096766/

WEBFeb 6, 2007 · CD39 is the cell surface-located prototypic member of the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. Biological actions of CD39 are a consequence (at least in part) of the regulated phosphohydrolytic activity on …

DA: 47 PA: 24 MOZ Rank: 27

CD39 Regulation and Functions in T Cells - PubMed
nih.gov

https://pubmed.ncbi.nlm.nih.gov/34360833/

WEBJul 28, 2021 · Abstract. CD39 is an enzyme which is responsible, together with CD73, for a cascade converting adenosine triphosphate into adenosine diphosphate and cyclic adenosine monophosphate, ultimately leading to the release of an immunosuppressive form of adenosine in the tumor microenvironment.

DA: 2 PA: 19 MOZ Rank: 62