1629–1631 Italian plague - Wikipedia
https://en.wikipedia.org/wiki/1629%E2%80%931631_Italian_plague
WEBEast of Lombardy, the Republic of Venice was infected in 1630–31. The city of Venice was severely hit, with recorded casualties of 46,000 out of a population of 140,000. Some historians believe that the drastic loss of life, and its impact on commerce, ultimately resulted in the downfall of Venice as a major commercial and political power. [4]
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