Keyword Analysis & Research: abasic

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  • AP site - Wikipedia

    wikipedia.org

    https://en.wikipedia.org/wiki/AP_site

    WebIn biochemistry and molecular genetics, an AP site ( apurinic/apyrimidinic site ), also known as an abasic site, is a location in DNA (also in RNA but much less likely) that has neither a purine nor a pyrimidine base, either spontaneously or due to DNA damage.

    DA: 68 PA: 48 MOZ Rank: 9

  • Sequencing abasic sites in DNA at single-nucleotide resolution

    nature.com

    https://www.nature.com/articles/s41557-019-0279-9

    WebJun 17, 2019 · Abasic sites, also known as AP sites, are one of the most common forms of damage products. The spontaneous hydrolysis of nucleobases generates an estimated 10,000 AP sites per cell, per day 1. AP...

    DA: 3 PA: 22 MOZ Rank: 47

  • New Insights into Abasic Site Repair and Tolerance - PMC

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299775/

    WebAbstract. Thousands of apurinic/apyrimidinic (AP or abasic) sites form in each cell, each day. This simple DNA lesion can have profound consequences to cellular function, genome stability, and disease. As potent blocks to polymerases, they interfere with the reading and copying of the genome.

    DA: 71 PA: 41 MOZ Rank: 35

  • Complex genomic patterns of abasic sites in mammalian DNA

    nature.com

    https://www.nature.com/articles/s41467-022-33594-1

    WebOpen access. Published: 05 October 2022. Complex genomic patterns of abasic sites in mammalian DNA revealed by a high-resolution SSiNGLe-AP method. Ye Cai, Huifen Cao, Fang Wang, Yufei Zhang &...

    DA: 83 PA: 41 MOZ Rank: 55

  • New insights into abasic site repair and tolerance☆,

    sciencedirect.com

    https://www.sciencedirect.com/science/article/pii/S1568786420301142

    WebJun 1, 2020 · Thousands of apurinic/apyrimidinic (AP or abasic) sites form in each cell, each day. This simple DNA lesion can have profound consequences to cellular function, genome stability, and disease. As potent blocks to polymerases, they interfere with the reading and copying of the genome.

    DA: 69 PA: 3 MOZ Rank: 9

  • Protection of abasic sites during DNA replication by a stable ... - Nature

    nature.com

    https://www.nature.com/articles/s41594-019-0255-5

    WebJun 24, 2019 · Abasic (AP) sites are one of the most common DNA lesions that block replicative polymerases. 5-hydroxymethylcytosine binding, embryonic stem cell-specific protein (HMCES) recognizes and processes...

    DA: 10 PA: 68 MOZ Rank: 35

  • New insights into abasic site repair and tolerance - PubMed

    nih.gov

    https://pubmed.ncbi.nlm.nih.gov/32417669/

    WebThousands of apurinic/apyrimidinic (AP or abasic) sites form in each cell, each day. This simple DNA lesion can have profound consequences to cellular function, genome stability, and disease. As potent blocks to polymerases, they interfere with the …

    DA: 84 PA: 62 MOZ Rank: 98

  • Molecular insight into how the position of an abasic site and its

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10401965/

    WebFormation of an abasic site (apurinic/apyrimidinic or AP site) results from the loss of a nucleobase through spontaneous or enzymatic cleavage of the glycosidic bond and is one of the most naturally abundant DNA lesions. ( 23, 24) Relative to mismatches, which may exhibit an array of non-canonical base-pairing configurations and structural defor...

    DA: 14 PA: 58 MOZ Rank: 11

  • Structural biology of DNA abasic site protection by SRAP proteins

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7494546/

    WebAbasic (AP) sites are one of the most frequently occurring types of DNA damage. They lead to DNA strand breaks, interstrand DNA crosslinks, and block transcription and replication. Mutagenicity of AP sites arises from translesion synthesis …

    DA: 50 PA: 39 MOZ Rank: 81

  • Abasic sites in DNA: repair and biological consequences in

    sciencedirect.com

    https://www.sciencedirect.com/science/article/pii/S1568786403002192

    WebJan 5, 2004 · Apurinic/apyrimidinic (AP) sites are one of the most frequent spontaneous lesions in DNA. They are potentially mutagenic and lethal lesions that can block DNA replication and transcription. In addition, cleavage of AP sites by AP endonucleases or AP lyases generates DNA single-strand breaks (SSBs) with 5′- or 3′-blocked ends, respectively.

    DA: 4 PA: 18 MOZ Rank: 58