Amide synthesis by acylation - Organic Chemistry
The one-pot reaction is promoted by propylphosphonic anhydride (T3P®) in the presence of 0.5 equivalents of HCl. L. Bannwart, S. Abele, S. Tortoioli, Synthesis, 2016, 48, 2069-2078. A palladium-catalyzed N-acylation of tertiary amines by carboxylic acids produces the corresponding amides in very good yields via cleavage of a C-N bond. Both ...
DA: 90 PA: 96 MOZ Rank: 95