Keyword Analysis & Research: ccr4

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What does CCR4 stand for?

CC chemokine receptor 4 (CCR4) is the receptor for two CC chemokine ligands (CCLs)-CCL17 (also called thymus- and activation-regulated chemokine) and CCL22 (macrophage-derived chemokine). Among the various T-cell subsets, CCR4 is predominantly expressed by Th2 cells, cutaneous lymphocyte antigen-positive skin-homing T cells and Treg cells.

What is CCCC receptor 4?

CC chemokine receptor 4 (CCR4) is the receptor for two CC chemokine ligands (CCLs)—CCL17 (also called thymus- and activation-regulated chemokine) and CCL22 (macrophage-derived chemokine). Among the various T-cell subsets, CCR4 is predominantly expressed by T h 2 cells, cutaneous lymphocyte antigen-positive skin-homing T cells and T reg cells.

What is CCR4 in cutaneous T-cell lymphoma?

CCR4 is often expressed on leukemic cells in cutaneous T-cell lymphoma (CTCL). Mogamulizumab is a humanised monoclonal antibody targeted at CCR4 and is an investigational drug for CTCL.

What is the role of CCR4 in asthma?

The dominant expression of CCR4 in T h2 cells makes it a potential therapeutic target for allergic diseases such as asthma and AD (113). Furthermore, because of the expression of CCR4 on T reg cells, CCR4 blockade may also be useful to enhance the efficacy of cancer vaccines (114).


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