Keyword Analysis & Research: circrna

wikipedia.org

https://en.wikipedia.org/wiki/Circular_RNA

Circular RNA (or circRNA) is a type of single-stranded RNA which, unlike linear RNA, forms a covalently closed continuous loop. In circular RNA, the 3' and 5' ends normally present in an RNA molecule have been joined together. This feature confers numerous properties to circular RNA, many of

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nih.gov

https://pubmed.ncbi.nlm.nih.gov/27050930/

CircRNAs are covalently closed, circular RNA molecules that typically comprise exonic sequences and are spliced at canonical splice sites. This feature of gene expression was first recognized in humans and mouse, but it quickly emerged that it was common across essentially all eukaryotes studied by molecular biologists. Author: Julia Salzman Publish Year: 2016

Author: Julia Salzman

Publish Year: 2016

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nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116471/

Aug 02, 2018 · CircRNAs are mainly synthesized by the transcription of protein-coding genes with RNA polymerase II (Pol II); but unlike linear RNAs, they are not produced by canonical mode of RNA splicing [ 5 ]. CircRNA molecules are circularized by joining the 3′ and 5′ ends together with unique back-splicing [ 6 ]. Author: Zhongrong Zhang, Tingting Yang, Junjie Xiao Publish Year: 2018

Author: Zhongrong Zhang, Tingting Yang, Junjie Xiao

Publish Year: 2018

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news-medical.net

https://www.news-medical.net/life-sciences/What-is-Circular-RNA-(CircRNA).aspx

CircRNA are known as micro RNA (miRNA) sponges due to their ability to bind to miRNA molecules and influence their function. They play a key role in the regulating miRNA target genes. Due their stability, circRNA can also act as protein decoys, bind and interact with a multitude of proteins. CircRNAs are transcriptional regulators and can be transl...

CircRNA are known as micro RNA (miRNA) sponges due to their ability to bind to miRNA molecules and influence their function. They play a key role in the regulating miRNA target genes. Due their stability, circRNA can also act as protein decoys, bind and interact with a multitude of proteins. CircRNAs are transcriptional regulators and can be transl...

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nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8113373/

May 11, 2021 · circRNAs are single-stranded circles of RNA, which form highly stable closed loops. circRNAs can have different functions. Among these, the miRNA sponging is the best-characterized role. circRNAs are widely expressed in human tissues and their expression is highly tissue-specific. Author: Lorena Verduci, Emilio Tarcitano, Sabrina Strano, Yosef Yarden, Giovanni Blandino Publish Year: 2021

Author: Lorena Verduci, Emilio Tarcitano, Sabrina Strano, Yosef Yarden, Giovanni Blandino

Publish Year: 2021

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sciencedirect.com

https://www.sciencedirect.com/science/article/pii/S0092867422004688

May 17, 2022 · A circRNA has the same primary sequence as its cognate linear RNA, except at the BSJ site ( Figure 1 A). Thus, discriminating a circRNA from its linear isoform has remained a challenge at multiple levels from annotation, validation, biogenesis to loss- and gain-of-function (LoF and GoF) studies ( Li et al., 2018c ).

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novogene.com

https://en.novogene.com/services/research-services/transcriptome-sequencing/non-coding-rna-sequencing/circular-rna-sequencing-circrna-seq/

Jun 02, 2020 · Circular RNA (circRNA) is a highly stable molecule of ncRNA, in form of a covalently closed loop that lacks the 5’end caps and the 3’ poly (A) tails. The circular structure grants circRNAs resistance against exonuclease digestion, a characteristic that can be exploited in library construction.

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nature.com

https://www.nature.com/articles/s41418-022-00948-7

Feb 15, 2022 · CircRNAs are covalently closed-loop molecules that lack 5′-caps and 3′-poly (A) tails and are resistant to RNA exonucleases-mediated degradation [ 9, 10 ]. The abundance of circRNAs is specific to...

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wikipedia.org

https://en.wikipedia.org/wiki/RNA

In the late 1970s, it was shown that there is a single stranded covalently closed, i.e. circular form of RNA expressed throughout the animal and plant kingdom (see circRNA). circRNAs are thought to arise via a "back-splice" reaction where the spliceosome joins a upstream 3' acceptor to a downstream 5' donor splice site. So far the function of ...

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