Keyword Analysis & Research: co1686 egfr

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Is radioiodinated co-1686 a useful tool for monitoring EGFR mutation monitoring?

Rociletinib (CO-1686), a 2,4-diaminopyrimidine derivative, is a highly potent tyrosine kinase inhibitor (TKI) that acts on epidermal growth factor receptor (EGFR) with L858R/T790M mutations. We supposed radioiodinated CO-1686 would function as a useful tool for monitoring EGFR L858R/T790M mutations. …

Is rociletinib (co-1686) an irreversible EGFR inhibitor?

For research use only. Rociletinib (CO-1686, AVL-301) is an irreversible, mutant-selective EGFR inhibitor with Ki of 21.5 nM and 303.3 nM for EGFR L858R/T790M and EGFR WT in cell-free assays, respectively. Phase 2.

What is the role of co-1686 in the pathophysiology of NSCLC?

CO-1686 selectively inhibits growth of NSCLC cells expressing mutant EGFR with GI50 ranging from 7 to 32 nM, and induces apoptosis. CO-1686–resistant NSCLC cell lines exhibits signs of epithelial-mesenchymal transition and increased sensitivity to AKT inhibitors.

What is EGFR?

What is eGFR? eGFR - Estimated glomerular filtration rate is the best test to measure your level of kidney function and determine your stage of kidney disease.


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