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|crash 3 txa||1.36||0.9||9855||95|
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When comparing CRASH-3 to the CRASH-2 traumatic brain sub-study, the most notable difference is that patients in CRASH-3 were often sicker. The overall rate of head injury-related death was 12% in the CRASH-2 sub-study, versus 19% in CRASH-3.What do we know about the Crash-3 study?
CRASH-3 is technically a “negative” study, as the primary endpoint falls slightly short of reaching statistical significance ( p >0.05). This likely resulted from the inclusion of some patients who were profoundly injured and unlikely to survive regardless of any therapy.What is the Crash-3 RCT?
CRASH-3 is the latest massive, pragmatic multi-center RCT brought to us by the London School of Hygiene and Tropical Medicine Trials Unit. These investigators have created an extensive network of hospitals throughout the world with the capability of performing truly impressive trials.