A New, Facile Synthesis of 1,4,7,10-Tetraazacyclododecane: Cyclen
https://pubs.acs.org/doi/10.1021/jo016111d
WEBMay 18, 2002 · Abstract. This report outlines a new and efficient synthesis of cyclen (1,4,7,10-tetraazacyclododecane, 1) utilizing bis-imidazoline, 6 (1,1‘-ethylenedi-2-imidazoline), with 1,2-dibromoethane. General conditions were developed, allowing for the simple, three-step synthesis of 1 at the multigram scale with an isolated overall yield …
DA: 68 PA: 63 MOZ Rank: 96