Graves' Disease Mechanisms: The Role of Stimulating, Blocking, …
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047290/
WebIn Graves' disease (GD), the main autoantigen is the thyroid stimulating hormone receptor (TSHR), which is expressed primarily in the thyroid but also in adipocytes, fibroblasts, bone cells, and a variety of additional sites including the heart [ 1 ]. The TSHR is a G-protein coupled receptor with 7 transmembrane-spanning domains ( Fig. 1a ).
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