HNH Nuclease | CRISPR/Cas9
The HNH nuclease domain of Cas9 cleaves the DNA strand complementary to the RNA guide. The HNH nuclease has a ββα-metal fold that comprises the active site shown to the right (Nishimasu et al. 2014).. There are many structural similarities between this nuclease and others that contain the ββα-metal fold, such as phage T4 endonuclease IIV and the Vibrio vulnificus nuclease, both of which ...
DA: 41 PA: 12 MOZ Rank: 5