Keyword Analysis & Research: hnmj

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hnmj0.840.34306484

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hnmj0.650.5249725

Search Results related to hnmj on Search Engine

  • iPSC-derived functional human neuromuscular junctions model …

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795289/

    WEBSep 9, 2019 · Abstract. The control of voluntary skeletal muscle contraction relies on action potentials, which send signals from the motor neuron through the neuromuscular junction (NMJ). Although dysfunction of the NMJ causes various neuromuscular diseases, a reliable in vitro system for disease modeling is currently unavailable.

    DA: 62 PA: 14 MOZ Rank: 28

  • Neuromuscular junction: Parts, structure and steps | Kenhub

    kenhub.com

    https://www.kenhub.com/en/library/anatomy/the-neuromuscular-junction-structure-and-function

    WEBOct 24, 2023 · At its simplest, the neuromuscular junction is a type of synapse where neuronal signals from the brain or spinal cord interact with skeletal muscle fibers, causing them to contract. The activation of many muscle fibers together causes muscles to contract, which in turn can produce movement.

    DA: 83 PA: 26 MOZ Rank: 72

  • iPSC-derived functional human neuromuscular junctions model …

    jci.org

    https://insight.jci.org/articles/view/124299

    WEBSep 19, 2019 · We propose our hNMJ model for investigating the physiology and pathology of hNMJs and for evaluating related therapeutic molecules. Results. Formation of hNMJs from iPSCs in a single well. The process of NMJ formation from hiPSCs in this study is illustrated in Figure 1.

    DA: 45 PA: 100 MOZ Rank: 9

  • Human neuromuscular junction on micro-structured microfluidic

    nih.gov

    https://pubmed.ncbi.nlm.nih.gov/34559171/

    WEBOct 26, 2021 · This study provides evidence for a physiologically relevant model to mimic a hNMJ that will in the future be a powerful tool, more sensitive than calcium imaging, to better understand and characterize NMJs and their …

    DA: 25 PA: 8 MOZ Rank: 53

  • Human neuromuscular junction on micro-structured ... - RSC …

    rsc.org

    https://pubs.rsc.org/en/content/articlelanding/2021/lc/d1lc00497b

    WEBSep 24, 2021 · This study provides evidence for a physiologically relevant model to mimic a hNMJ that will in the future be a powerful tool, more sensitive than calcium imaging, to better understand and characterize NMJs and their …

    DA: 74 PA: 5 MOZ Rank: 39

  • Cellular and Molecular Anatomy of the Human Neuromuscular …

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723673/

    WEBNov 11, 2017 · The neuromuscular junction (NMJ) plays a fundamental role in transferring information from lower motor neuron to skeletal muscle to generate movement. It is also an experimentally accessible model synapse routinely studied in animal models to explore fundamental aspects of synaptic form and function.

    DA: 65 PA: 62 MOZ Rank: 100

  • Stem cell derived phenotypic human neuromuscular junction …

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866791/

    WEBThere are currently no functional neuromuscular junction (hNMJ) systems composed of human cells that could be used for drug evaluations or toxicity testing in vitro. These systems are needed to evaluate NMJs for diseases such as amyotrophic lateral sclerosis, spinal muscular atrophy or other neurodegenerative diseases or injury states.

    DA: 3 PA: 72 MOZ Rank: 32

  • Bioengineered optogenetic model of human neuromuscular junction

    sciencedirect.com

    https://www.sciencedirect.com/science/article/pii/S0142961221003896

    WEBSep 1, 2021 · Here we describe a standardized method for engineering an isogenic, patient specific human neuromuscular junction (NMJ) that allows for automated quantification of NMJ function to diagnose disease using a small sample of blood serum and evaluate new therapeutic modalities.

    DA: 8 PA: 29 MOZ Rank: 1

  • Stem cell derived phenotypic human neuromuscular junction ... - PubMed

    nih.gov

    https://pubmed.ncbi.nlm.nih.gov/29547745/

    WEBThere are currently no functional neuromuscular junction (hNMJ) systems composed of human cells that could be used for drug evaluations or toxicity testing in vitro. These systems are needed to evaluate NMJs for diseases such as amyotrophic lateral sclerosis, spinal muscular atrophy or other neurode …

    DA: 41 PA: 81 MOZ Rank: 45

  • Engineering the next generation of human skeletal

    sciencedirect.com

    https://www.sciencedirect.com/science/article/pii/S2468451120300222

    WEBDec 1, 2020 · Current hNMJ models combine PSC-derived MNs with either PSC-derived myogenic progenitors [14, 15] or primary myoblasts [6, 16]. They have successfully demonstrated aspects of hNMJ function, maturation, and pathology ( Table 1 ).

    DA: 86 PA: 29 MOZ Rank: 56