Exploring peptide/MHC detachment processes using …
https://academic.oup.com:443/bioinformatics/article/32/2/181/1743111
1 Introduction2 Methods3 Results4 Discussion5 ConclusionAcknowledgementsFunding3.1 HNMMC gives insights into the peptide detachment processes 3.1 HNMMC gives insights into the peptide detachment processesIn Figure 2A, we show a representative detachment process of the experimentally known non-binding peptide AAAKTPVIV. Using our HNMMC protocol, important conformational states for the partial peptide detachment process of this peptide can be located within 25 000 steps. These stat… 3.2 Putative peptide detachment pathwaysHaving demonstrated that the methodology is able to simulate peptide detachment and that the results show agreement with classical methods, we then simulated 32 different peptides and repeated each simulation 100 times with different random initial seeds to initiate stochastically diff… Author: Bernhard Knapp, Samuel Demharter, Charlotte M. Deane, Peter Minary Publish Year: 2015 Published: Jan 15, 2016
3.1 HNMMC gives insights into the peptide detachment processesIn Figure 2A, we show a representative detachment process of the experimentally known non-binding peptide AAAKTPVIV. Using our HNMMC protocol, important conformational states for the partial peptide detachment process of this peptide can be located within 25 000 steps. These stat…
3.2 Putative peptide detachment pathwaysHaving demonstrated that the methodology is able to simulate peptide detachment and that the results show agreement with classical methods, we then simulated 32 different peptides and repeated each simulation 100 times with different random initial seeds to initiate stochastically diff…
Author: Bernhard Knapp, Samuel Demharter, Charlotte M. Deane, Peter Minary
Publish Year: 2015
Published: Jan 15, 2016
DA: 94 PA: 55 MOZ Rank: 41
