|modafinil qt prolongation||0.57||0.6||7920||2|
Lithium concentrations > 1.2 mmol, however, can markedly prolong the QTc interval. Lamotrigine, topiramate and valproate do not show significant QTc interval prolongation. No significant changes to QTc interval with long-term treatment with methylphenidate or amphetamine drugs. Atomoxetine can be associated with life-threatening long QT syndrome.What is QT prolongation and what causes it?
QT prolongation is an established side effect of anti-arrhythmic medicines, but can also be caused by a wide range of non-cardiac medicines, including antibiotics, antihistamines, opioid analgesics and complementary medicines. On an EKG, the QT interval represents the summation of action potentials in cardiac muscle...Does citalopram cause QT interval prolongation?
It is also important to keep in mind that, for some patients, the risk of QTc interval prolongation with 60mg of citalopram is not as significant as the risk of psychiatric decompensation with a lower dose.Is modafinil safe for heart patients with mitral valve prolapse?
Nonetheless, package labels have similar cardiovascular warnings to the stimulant drugs. Exclusive to modafinil and armodafinil is the warning against use in patients with history of left ventricular hypertrophy or in those with mitral valve prolapse who have experienced mitral valve prolapse with previous CNS stimulant use.