Keyword Analysis & Research: nigro protocol

wikipedia.org

https://en.wikipedia.org/wiki/Nigro_protocol

WEBNigro protocol is the preoperative use of chemotherapy with 5-fluorouracil and mitomycin and medical radiation for squamous cell carcinomas of the anal canal. [1] [2] Success of the preoperative regimen changed the paradigm of anal cancer treatment from surgical to non-surgical and was the advent of definitive chemoradiation (omitting surgery ...

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wiley.com

https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21712

WEBNov 30, 2021 · The initial Nigro regimen consisted of a fluoropyrimidine, 5-fluorouracil (5-FU) (1000 mg/m 2 as a continuous infusion on days 1-4 and 29-32) and mitomycin-C (MMC) (10-15 mg/m 2 on day 1) with concurrent radiation to a total dose of 30 gray (Gy). 6 The first 3 patients treated with this protocol experienced complete regression of their tumor ...

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analcancerfoundation.org

https://www.analcancerfoundation.org/treatment/

WEBThe Nigro Protocol. The standard protocols for treating anal cancer are listed in the NCCN guidelines and on the NHS website (UK). For stages I – III, the standard protocol is radiation and chemotherapy, used in conjunction with one another (often called 'chemoradiation').

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nih.gov

https://www.ncbi.nlm.nih.gov/books/NBK537342/

WEBFeb 28, 2023 · After the Nigro protocol demonstrated a high rate of complete pathologic response to neoadjuvant chemoradiation, there was the development of multiple randomized clinical trials to validate definitive chemoradiation as primary treatment of anal cancer.

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nejm.org

https://www.nejm.org/doi/full/10.1056/NEJMoa2201048

WEBJun 15, 2022 · Clinicians selected the method of treatment from a list of protocol-defined options, in accordance with clinician and participant preference, using method-specific algorithms (Fig. S2A and S2B). nigro

nigro

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wiley.com

https://acsjournals.onlinelibrary.wiley.com/doi/pdf/10.3322/caac.21712

WEBin the Nigro protocol. With radiation dose escalation and optimization of the chemotherapy regimen, the results demonstrated 5- year OS rates ranging from 70% to 90% and 5-year CFS rates ranging from 70% to 86%. Overall, these FIGURE 1.

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nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4177484/

WEBSep 9, 2014 · Treatment of anal cancer is dependent on location and stage. Anal canal cancer is primarily treated with chemoradiation. Since Dr. Nigro’s protocol was reported several iterations of therapy have been explored. Chemotherapy with radiation vs radiation alone has been evaluated in multicenter, prospective, randomized controlled trials.

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jamanetwork.com

https://jamanetwork.com/journals/jamasurgery/fullarticle/391920

WEBSpawned by impressive data from larger case series detailing improved survival, lower local recurrence rates, and the reduction in the number of permanent colostomies, the "Nigro protocol" became the standard of care despite the absence of controlled trials.

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nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074958/

WEBApr 1, 2014 · The Nigro CRT protocol demonstrated equivalent efficacy to APR, but was not compared head to head, and lead to a major shift in the management of anal SCC ( 7, 9 ). In subsequent years, multiple randomized trials were conducted to …

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springer.com

https://link.springer.com/article/10.1007/s11912-016-0503-3

WEBFeb 24, 2016 · Since 1974, numerous studies have explored disease outcomes with the Nigro protocol [6, 34, 35]. Subsequent studies have confirmed that, when compared to surgery, the Nigro protocol yields significant improvements in OS, colostomy-free survival (CFS), and nodal relapse rates [ 4 ].

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