propofol half life | Propofol - StatPearls - NCBI Bookshelf

Keyword	CPC	PCC	Volume	Score	Length of keyword
propofol half life	0.28	0.5	5645	60	18
propofol	1.61	0.8	2016	33	8
half	1.29	0.3	1505	81	4
life	1.18	1	9257	69	4

Keyword	CPC	PCC	Volume	Score
propofol half life	1.63	0.6	915	5

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Propofol - StatPearls - NCBI Bookshelf - National Center for
nih.gov

https://www.ncbi.nlm.nih.gov/books/NBK430884/

WEBJul 24, 2023 · Half-life: Propofol is bi-phasic, with its initial half-life being relatively quick, around 40 minutes, and its terminal half-life usually being 4 to 7 hours. Context-sensitive half-time may be up to 1 to 3 days after a 10-day infusion.

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Propofol - Wikipedia
wikipedia.org

https://en.wikipedia.org/wiki/Propofol

WEBPropofol is highly protein-bound in vivo and is metabolized by conjugation in the liver. The half-life of elimination of propofol has been estimated to be between 2 and 24 hours. However, its duration of clinical effect is much shorter, because propofol is rapidly distributed into peripheral tissues.

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Clinical Pharmacokinetics and Pharmacodynamics of Propofol
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267518/

WEBJul 18, 2018 · The ranges of published noncompartmental PK parameters for adults after propofol infusion are Vd ss 159–771 L, half-life of fast distribution (T ½α) 1.33–4.6 min, half-life of slow distribution (T ½β) 27–69.3 min, half-life of elimination (T ½γ) 116–834 min, mean residence time (MRT) 102–174 min, total blood clearance (Cl b) 1. ...

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Propofol Monograph for Professionals - Drugs.com
drugs.com

https://www.drugs.com/monograph/propofol.html

WEBOct 27, 2023 · Propofol (Monograph) Brand name: Diprivan. Drug class: General Anesthetics, Miscellaneous. VA class: CN203. Medically reviewed by Drugs.com on Oct 27, 2023. Written by ASHP. Introduction. Uses. Dosage. Warnings. Interactions. Stability. Introduction. Sedative and hypnotic. Uses for Propofol. Induction and Maintenance of …

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Propofol: Dosage, Mechanism/Onset of Action, Half-Life - Medicine…
medicine.com

https://www.medicine.com/drug/propofol/hcp

WEBFeb 17, 2020 · Half-Life Elimination. Biphasic: Initial: 40 minutes; Terminal: 4 to 7 hours (after 10-day infusion, may be up to 1 to 3 days) Protein Binding. 97% to 99%. Use in Specific Populations Special Populations: Elderly. With increasing age, the dose requirement decreases because of occurrence of higher peak plasma concentrations. …

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The Experimental and Clinical Pharmacology of Propofol, an …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494023/

WEBMay 14, 2008 · The terminal half‐life of propofol after a 10‐day infusion is 1–3 days (AstraZeneca 2001). If there are higher than necessary infusion levels of plasma, this return of propofol from the peripheral tissues will delay recovery.

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Propofol: Uses, Interactions, Mechanism of Action | DrugBank …
drugbank.com

https://go.drugbank.com/drugs/DB00818

WEBPropofol. DrugBank Accession Number. DB00818. Background. Propofol is an intravenous anaesthetic agent used for induction and maintenance of general anaesthesia. IV administration of propfol is used to induce unconsciousness after which anaesthesia may be maintained using a combination of medications.

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Clinical Pharmacology of Propofol: An Intravenous Anesthetic Agent
sagepub.com

https://journals.sagepub.com/doi/pdf/10.1177/106002808902301001

WEBThe blood concentration-time profile of propofol after an iv bolus injection follows a three-compartment model with half-lives of 2–4 min, 30–45 min, and 3–63 h, respectively. Propofol is extensively metabolized by the liver prior to its elimination by the kidney.

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Propofol | Anesthesiology | American Society of Anesthesiologists
asahq.org

https://pubs.asahq.org/anesthesiology/article/109/6/1132/10512/PropofolIts-Role-in-Changing-the-Practice-of

WEBPatients undergoing major (intraabdominal) surgery had longer elimination half-life values (136 +/- 40 vs. 108 +/- 29 min). Patients required an average blood propofol concentration of 4.05 +/- 1.01 micrograms/ml for major surgery and 2.97 +/- …

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PROPOFOL (CIVICA) Clinical Pharmacology - Pfizer Medical …
pfizermedicalinformation.com

https://www.pfizermedicalinformation.com/propofol-civica/clinical-pharmacology

WEBThe terminal half-life of propofol after a 10-day infusion is 1 day to 3 days. Geriatrics With increasing patient age, the dose of propofol needed to achieve a defined anesthetic end point (dose-requirement) decreases.

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