CircRNA derived from introns is known as circular intronic RNA (ciRNA). It was found to be abundant in the nucleus, reported firstly in human cells and was suggested to have a regulatory role in their parent coding genes. They represent a small part of circRNA, of which only 19.2% exists in humans [ 37 ]. and a very small fraction in plants.What is circrna_010567?
A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-β1. Biochem Biophys Res Commun. 2017;487 (4):769–75. 112. Zhao Z, Li X, Gao C, Jian D, Hao P, Rao L, Li M. Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease.What is the best book on circular RNA?
Zhang, Y. et al. Circular intronic long noncoding RNAs. Mol. Cell 51, 792–806 (2013). 4. Lasda, E. & Parker, R. Circular RNAs: diversity of form and function. RNA 20, 1829–1842 (2014). 5. Li, X., Yang, L. & Chen, L. L.How many read counts are needed to detect circRNA?
For circRNA, a detection threshold of 5-reads was applied to avoid “shot noises” for low read counts (Anders et al., 2010). All clustering was performed with a hierarchical clustering method using Manhattan Distance.