sialoglycan | Sialoglycan binding triggers spike opening in a human co

Keyword	CPC	PCC	Volume	Score	Length of keyword
sialoglycan	0.46	1	7571	5	11

Keyword	CPC	PCC	Volume	Score
sialoglycan	1.03	0.1	547	24

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Sialoglycan binding triggers spike opening in a human coronavirus
nature.com

https://www.nature.com/articles/s41586-023-06599-z

WEBOct 4, 2023 · Here, using cryogenic electron microscopy and molecular dynamics simulations, we show that the spike protein of the common cold human coronavirus HKU1 undergoes local and long-range conformational...

DA: 84 PA: 17 MOZ Rank: 86

Engagement of sialylated glycans with Siglec receptors on
nature.com

https://www.nature.com/articles/s41423-024-01142-0

WEBMar 6, 2024 · The Siglec-sialoglycan axis in cancer is a potential immune checkpoint target for cancer immunotherapy that can be modulated by blocking Siglec receptors or cleaving sialoglycans via...

DA: 34 PA: 28 MOZ Rank: 47

Sialoglycans and Siglecs Can Shape the Tumor Immune ... - PubMed
nih.gov

https://pubmed.ncbi.nlm.nih.gov/32139317/

WEBRecent studies have shown that tumor cells can exploit sialoglycan-Siglec interactions to modulate immune cell function, contributing to an immunosuppressive tumor microenvironment (TME). Interference with sialoglycan synthesis or sialoglycan-Siglec interactions might improve antitumor immunity.

DA: 20 PA: 23 MOZ Rank: 76

Targeting the Siglec–Sialic Acid Immune Axis in Cancer: Current …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9716255/

WEBDec 12, 2022 · The sialic acid–binding immunoglobulin-like lectin (Siglec)–sialic acid immune axis is an evolutionarily conserved immunoregulatory pathway that provides a mechanism for establishing self-recognition and combatting invasive pathogens.

DA: 71 PA: 67 MOZ Rank: 30

Breaking the Convention: Sialoglycan Variants, Coreceptors, and
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997770/

WEBJan 31, 2020 · In this review, we discuss sialoglycan variants and potential coreceptors, which contribute to IAV attachment and internalization beyond the well-described α2,3- and α2,6-linked sialic acid receptor specificities of HA.

DA: 26 PA: 44 MOZ Rank: 20

Involvement of sialoglycans in SARS‐COV‐2 infection: …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9877878/

WEBNov 19, 2022 · Involvement of sialoglycans in SARS‐COV‐2 infection: Opportunities and challenges for glyco‐based inhibitors - PMC. Journal List. Wiley - PMC COVID-19 Collection. PMC9877878. As a library, NLM provides access to scientific literature.

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Sialoglycans and Siglecs Can Shape the Tumor Immune
sciencedirect.com

https://www.sciencedirect.com/science/article/pii/S1471490620300211

WEBApr 1, 2020 · Sialoglycans can be recognized by sialic acid-binding immunoglobulin-like lectins (Siglecs), a family of immunomodulatory receptors. Most mammalian Siglecs transmit inhibitory signals comparable with the immune checkpoint inhibitor programmed death protein 1 (PD-1), but some are activating.

DA: 58 PA: 46 MOZ Rank: 4

Targeted glycan degradation potentiates the anticancer immune ... - Nature
nature.com

https://www.nature.com/articles/s41589-020-0622-x

WEBAug 17, 2020 · One such mechanism is an upregulation of sialoglycans in malignancy, which has been recently shown to inhibit immune cell activation through multiple mechanisms and therefore represents a...

DA: 88 PA: 46 MOZ Rank: 37

Sialoglycans and Siglecs Can Shape the Tumor Immune …
cell.com

https://www.cell.com/trends/immunology/pdf/S1471-4906(20)30021-1.pdf

WEBSialic acid sugar-carrying glycans, sialoglycans, are aberrantly expressed on many tumor cells and have emerged as potent regulatory molecules involved in creating a tumor-supportive microenvironment. Sialoglycans can be recognized by sialic acid-binding immunoglobulin-like lectins (Siglecs), a family of immunomodulatory receptors.

DA: 59 PA: 77 MOZ Rank: 89

Sialoglycans and Siglecs Can Shape the Tumor Immune …
cell.com

https://www.cell.com/trends/immunology/fulltext/S1471-4906(20)30021-1

WEBSialic acid sugar-carrying glycans, sialoglycans, are aberrantly expressed on many tumor cells and have emerged as potent regulatory molecules involved in creating a tumor-supportive microenvironment. Sialoglycans can be recognized by sialic acid-binding immunoglobulin-like lectins (Siglecs), a family of immunomodulatory receptors.

DA: 89 PA: 36 MOZ Rank: 81