WebApr 3, 2024 · TFRC (Transferrin Receptor) is a Protein Coding gene. Diseases associated with TFRC include Immunodeficiency 46 and Combined Immunodeficiency.Among its related pathways are Signaling by Rho GTPases and RHOC GTPase cycle.Gene Ontology (GO) annotations related to this gene include RNA binding and double-stranded RNA binding.An important paralog of this gene is TFR2.
WebTransferrin receptor 1. Transferrin receptor protein 1 ( TfR1 ), also known as C luster of D ifferentiation 71 ( CD71 ), is a protein that in humans is encoded by the TFRC gene. [5] [6] TfR1 is required for iron import from transferrin into cells by endocytosis. [7] [8]
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TFRC upregulation promotes ferroptosis in CVB3 infection via …
WebJul 11, 2022 · Cell viability. HeLa cells were seeded in 96‐well plates (5 × 10 3 cells/well). After 24 h, when the cells grew into a monolayer, they were infected with CVB3 and were harvested at different times.
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TRIB2 desensitizes ferroptosis via βTrCP-mediated TFRC
WebJul 27, 2021 · TRIB2 is a pseudokinase that has a major function to act as a molecular adaptor mediating protein ubiquitination and followed destabilization via E3s [].An unique feature distinguishing TRIB2 from ...
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MYCN mediates TFRC-dependent ferroptosis and reveals
WebMay 19, 2021 · MYCN is a regulator of GPX4-dependent ferroptosis. To study MYCN-dependent cellular processes in NB, we examined a collection of 147 genes essential for the survival of MYCN-amplified NB cells 17 ...
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Role of TFRC as a Novel Prognostic Biomarker and in …
WebMar 16, 2022 · Objective: To explore the expression of the transferrin receptor (TFRC) gene in pancreatic cancer and to analyze the pathogenesis and immunotherapy of TFRC in patients using bioinformatics methods. Methods: We used public data from the cancer genome atlas (TCGA) and gene expression omnibus databases to explore the expression level of the TFRC gene in pancreatic cancer patients.
WebAR TFRC deficiency ( TFRC; OMIM # 616744) Definition: The TFRC gene encodes the transferrin receptor, which is important for cellular iron uptake. A missense mutation in TFRC, encoding transferrin receptor 1, causes this AR-CID. 169. Genetics: Homozygous missense mutations in the TFRC gene (Y20H) was reported in affected members of a …
WebApr 7, 2024 · Summary. This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015] Expression.
WebSummary. This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
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TFRC - What does TFRC stand for? The Free Dictionary
