Casr.ca - Calcium-sensing receptor - Wikipedia

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WebThe calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ions. It is primarily expressed in the parathyroid gland, the renal tubules of the kidney and the brain. In the parathyroid gland, it controls calcium homeostasis by regulating the release of parathyroid hormone (PTH).

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Calcium-sensing receptor - Wikipedia
wikipedia.org

https://en.wikipedia.org/wiki/Calcium-sensing_receptor

WebThe calcium-sensing receptor (CaSR) is a Class C G-protein coupled receptor which senses extracellular levels of calcium ions. It is primarily expressed in the parathyroid gland, the renal tubules of the kidney and the brain. In the parathyroid gland, it controls calcium homeostasis by regulating the release of parathyroid hormone (PTH).

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The calcium-sensing receptor in physiology and in calcitropic ... - Nature
nature.com

https://www.nature.com/articles/s41574-018-0115-0

WebNov 15, 2018 · This Review focuses on the evolutionary origins, structure and signalling pathways of the Ca2+-sensing receptor (CaSR), as well as the roles of the CaSR in calcitropic and noncalcitropic diseases.

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CASR gene: MedlinePlus Genetics
medlineplus.gov

https://medlineplus.gov/genetics/gene/casr/

WebThe CASR gene provides instructions for making a protein called the calcium-sensing receptor (CaSR). Calcium molecules attach (bind) to CaSR, which allows this protein to monitor and regulate the amount of calcium in the blood. The receptor is turned on (activated) when a certain concentration of calcium is reached, and the activated receptor ...

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Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7957814/

WebMar 1, 2021 · The calcium Sensing Receptor (CaSR) is a cell surface receptor belonging to the family of G-protein coupled receptors. CaSR is mainly expressed by parathyroid glands, kidneys, bone, skin, adipose tissue, the gut, the nervous …

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CASR Gene - GeneCards | CASR Protein | CASR Antibody
genecards.org

https://www.genecards.org/cgi-bin/carddisp.pl?gene=CASR

WebApr 2, 2024 · CASR (Calcium Sensing Receptor) is a Protein Coding gene. Diseases associated with CASR include Hyperparathyroidism, Neonatal Severe and Hypocalciuric Hypercalcemia, Familial, Type I. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

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Calcium-sensing receptor signaling — How human disease …
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7611003/

WebThe CaSR is widely expressed and has diverse physiological functions indicating tissue- or ligand-specific CaSR signaling may exist. Two recent publications provide possible insights into this phenomenon. CaSR activation in osteoblasts is essential for differentiation and bone remodeling .

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The role of calcium-sensing receptor signaling in regulating
nih.gov

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8606958/

WebApr 29, 2021 · The calcium-sensing receptor (CaSR) plays a critical role in sensing extracellular calcium (Ca 2+) and signaling to maintain Ca 2+ homeostasis. In the parathyroid, the CaSR regulates secretion of parathyroid hormone, which functions to increase extracellular Ca 2+ levels.

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Extracellular calcium alters calcium-sensing receptor network
nature.com

https://www.nature.com/articles/s41598-021-00067-2

WebOct 18, 2021 · The calcium-sensing receptor (CaSR), a family C GPCR, regulates systemic calcium (Ca2+) homeostasis that is critical for many physiological, calciotropical, and noncalciotropical...

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Structural mechanism of cooperative activation of the human
nature.com

https://www.nature.com/articles/s41422-021-00474-0

WebFeb 18, 2021 · Nature Communications (2022) The human calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor (GPCR) responsible for maintaining Ca2+ homeostasis in...

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Calcium-sensing receptor (CaSR): Pharmacological properties …
sciencedirect.com

https://www.sciencedirect.com/science/article/pii/S1521690X13000717

WebJun 1, 2013 · In this article we consider the mechanisms by which the calcium-sensing receptor (CaSR) induces its cellular responses via the control (activation or inhibition) of signaling pathways. We consider key features of CaSR-mediated signaling including its control of the heterotrimeric G-proteins G q/11, G i/o and G 12/13 and the downstream ...

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Host	Type	Class	TTL	Extra
casr.ca	SOA	IN	3600	Mname: ns1.softlayer.com Rname: support.softlayer.com Serial: 1496420014 Refresh: 7200 Retry: 600 Expire: 1728000 Minimum-ttl: 43200
casr.ca	TXT	IN	3600	Txt: v=spf1 mx ~all Entries_0: v=spf1 mx ~all
casr.ca	A	IN	3600	Ip: 158.85.87.76
casr.ca	MX	IN	3600	Pri: 10 Target: mail.casr.ca
casr.ca	NS	IN	3600	Target: slns2.namespro.ca
casr.ca	NS	IN	3600	Target: slns1.namespro.ca

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IP	158.85.87.76
Domain infomation	Domain Name: casr.ca Registry Domain ID: 39289667-CIRA Registrar WHOIS Server: whois.ca.fury.ca Registrar URL: https://www.namespro.ca Updated Date: 2024-03-22T19:50:38Z Creation Date: 2017-03-22T19:46:59Z Registry Expiry Date: 2025-03-22T19:46:59Z Registrar: Namespro Solutions Inc. Registrar IANA ID: not applicable Registrar Abuse Contact Email: [email protected] Registrar Abuse Contact Phone: +1.6046818007 Domain Status: autoRenewPeriod https://icann.org/epp#autoRenewPeriod Domain Status: clientTransferProhibited https://icann.org/epp#clientTransferProhibited Registry Registrant ID: R373450-CIRA Registrant Name: Maser Media Inc Registrant Organization: Maser Media Inc Registrant Street: 2880 Queen Street East Unit 4 Suite 206 Registrant City: Brampton Registrant State/Province: ON Registrant Postal Code: L6S6E8 Registrant Country: CA Registrant Phone: +1.4162198857 Registrant Phone Ext: Registrant Fax: Registrant Fax Ext: Registrant Email: [email protected] Registry Admin ID: C1520782-CIRA Admin Name: AM Gonsalves Admin Organization: Admin Street: 2880 Queen Street East Unit 4 Suite 206 Admin City: Brampton Admin State/Province: ON Admin Postal Code: L6S6E8 Admin Country: CA Admin Phone: +1.4162198857 Admin Phone Ext: Admin Fax: Admin Fax Ext: Admin Email: [email protected] Registry Tech ID: C1841520-CIRA Tech Name: AM Gonsalves Tech Organization: Tech Street: 2880 Queen Street East Unit 4 Suite 206 Tech City: Brampton Tech State/Province: ON Tech Postal Code: L6S6E8 Tech Country: CA Tech Phone: +1.4162198857 Tech Phone Ext: Tech Fax: Tech Fax Ext: Tech Email: [email protected] Registry Billing ID: Billing Name: Billing Organization: Billing Street: Billing City: Billing State/Province: Billing Postal Code: Billing Country: Billing Phone: Billing Phone Ext: Billing Fax: Billing Fax Ext: Billing Email: Name Server: slns1.namespro.ca Name Server: slns2.namespro.ca DNSSEC: unsigned URL of the ICANN Whois Inaccuracy Complaint Form: https://www.icann.org/wicf/ >>> Last update of WHOIS database: 2024-04-19T11:17:52Z <<< For more information on Whois status codes, please visit https://icann.org/epp % % Use of CIRA's WHOIS service is governed by the Terms of Use in its Legal % Notice, available at http://www.cira.ca/legal-notice/?lang=en % % (c) 2024 Canadian Internet Registration Authority, (http://www.cira.ca/)