Ifsp1.tv - Molecular characterization of AIFM2/FSP1 inhibition by iFSP1-like

Provided by Alexa ranking, ifsp1.tv has ranked N/A in N/A and 4,021,397 on the world. ifsp1.tv reaches roughly 770 users per day and delivers about 23,107 users each month. The domain ifsp1.tv uses a Commercial suffix and it's server(s) are located in N/A with the IP number 103.224.212.213 and it is a .tv domain.

WebApr 21, 2023 · Ferroptosis suppressor protein 1 (FSP1), an NAD (P)H-ubiquinone reductase, is a key determinant of ferroptosis vulnerability, and its pharmacological inhibition was shown to strongly sensitize...

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  • Molecular characterization of AIFM2/FSP1 inhibition by iFSP1-like

    nature.com

    https://www.nature.com/articles/s41419-023-05787-z

    WebApr 21, 2023 · Ferroptosis suppressor protein 1 (FSP1), an NAD (P)H-ubiquinone reductase, is a key determinant of ferroptosis vulnerability, and its pharmacological inhibition was shown to strongly sensitize...

    DA: 15 PA: 97 MOZ Rank: 50

  • FSP1 is a glutathione-independent ferroptosis suppressor

    nature.com

    https://www.nature.com/articles/s41586-019-1707-0

    WebOct 21, 2019 · Treatment with the ferroptosis inhibitor Lip-1 (150 nM) protected GPX4-knockout cells from iFSP1-induced ferroptosis. iFSP1 is only toxic to cells that depend solely (no GPX4 expression...

    DA: 92 PA: 89 MOZ Rank: 2

  • Integrated chemical and genetic screens unveil FSP1 …

    nature.com

    https://www.nature.com/articles/s41594-023-01136-y

    WebNov 13, 2023 · Ferroptosis suppressor protein-1 (FSP1), as the second ferroptosis mainstay, efficiently prevents lipid peroxidation via NAD (P)H-dependent reduction of quinones. Because its molecular...

    DA: 35 PA: 83 MOZ Rank: 26

  • Ferroptosis Suppressor Protein 1 Inhibition Promotes Tumor

    nih.gov

    https://pubmed.ncbi.nlm.nih.gov/36893885/

    WebWe also demonstrated that iFSP1 worked synergistically with immunotherapies to suppress HCC progression. Conclusions: We identified FSP1 as a novel, vulnerable therapeutic target in HCC. The inhibition of FSP1 potently induced ferroptosis, which promoted innate and adaptive anti-tumor immune responses and effectively suppressed HCC tumor growth.

    DA: 38 PA: 26 MOZ Rank: 17

  • FSP1-mediated ferroptosis in cancer: from mechanisms to

    springer.com

    https://link.springer.com/article/10.1007/s10495-024-01966-1

    Web4 days ago · Therefore, whether the combination of iFSP1 and GPX4 inhibitors can reduce the damage to T cells when ferroptosis inhibition is a question worth studying, which may provide a new idea for the combination of ferroptosis inducers. The combination of iFSP1 and GPX4 inhibitors reduces drug resistance in tumor cells.

    DA: 49 PA: 66 MOZ Rank: 53

  • The anti-ferroptotic role of FSP1: current molecular mechanism …

    springer.com

    https://link.springer.com/article/10.1186/s43556-022-00105-z

    WebNov 29, 2022 · FSP1 mainly localizes to the periphery of lipid droplets and to the plasma membrane. It also partly overlaps with the endoplasmic reticulum and Golgi. Bersuker et al. and Doll et al. independently reported that N-myristylation of FSP1 is essential for its anti-ferroptotic activity [ 3, 4 ].

    DA: 9 PA: 37 MOZ Rank: 12

  • Molecular characterization of AIFM2/FSP1 inhibition by iFSP1-like

    nih.gov

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10119282/

    WebApr 21, 2023 · Ferroptosis suppressor protein 1 (FSP1), an NAD (P)H-ubiquinone reductase, is a key determinant of ferroptosis vulnerability, and its pharmacological inhibition was shown to strongly sensitize cancer cells to ferroptosis.

    DA: 23 PA: 56 MOZ Rank: 35

  • Ferroptosis Suppressor Protein 1 Inhibition Promotes

    sciencedirect.com

    https://www.sciencedirect.com/science/article/pii/S2352345X23000383

    WebJan 1, 2023 · The CoQ 10 /FSP1 pathway is another protective pathway against ferroptosis that works independently of the cysteine/GSH/GPX4 pathway. 14, 15 A potent FSP1 inhibitor, iFSP1, was identified. iFSP1 induced ferroptosis and suppressed cancer cell growth in vitro with GPX4 inhibited.

    DA: 41 PA: 68 MOZ Rank: 54

  • FSP1 is a glutathione-independent ferroptosis suppressor

    nih.gov

    https://pubmed.ncbi.nlm.nih.gov/31634899/

    WebFerroptosis is an iron-dependent form of necrotic cell death marked by oxidative damage to phospholipids 1,2. To date, ferroptosis has been thought to be controlled only by the phospholipid hydroperoxide-reducing enzyme glutathione peroxidase 4 (GPX4) 3,4 and radical-trapping antioxidants 5,6.

    DA: 13 PA: 37 MOZ Rank: 69

  • FSP1: a key regulator of ferroptosis - ScienceDirect

    sciencedirect.com

    https://www.sciencedirect.com/science/article/pii/S1471491423001119

    WebSep 1, 2023 · Ferroptosis suppressor protein 1 (FSP1) an important regulator of ferroptosis independent of GSH and works in parallel with glutathione peroxidase 4 (GPX4). Glutathione (GSH) it is composed of glutamic acid, cysteine, and glycine, and exerts antioxidant and integrated detoxification effects.

    DA: 10 PA: 17 MOZ Rank: 19

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DNS Record

Host Type Class TTL Extra
ifsp1.tv A IN 3600 Ip: 103.224.212.213
ifsp1.tv TXT IN 3600 Txt: v=spf1 ip6:fdcf:abda:4154::/48 -all
Entries_0: v=spf1 ip6:fdcf:abda:4154::/48 -all
ifsp1.tv SOA IN 60 Mname: ns1.abovedomains.com
Rname: hostmaster.trellian.com
Serial: 2024041901
Refresh: 10800
Retry: 3600
Expire: 604800
Minimum-ttl: 3600
ifsp1.tv NS IN 21600 Target: ns2.abovedomains.com
ifsp1.tv NS IN 21600 Target: ns1.abovedomains.com
ifsp1.tv MX IN 3600 Pri: 10
Target: park-mx.above.com

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