Keyword Analysis & Research: cd3 tcr

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Keyword CPC PCC Volume Score Length of keyword
cd3 tcr0.950.62519217
cd30.170.5286853
tcr1.920.83668783

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Keyword CPC PCC Volume Score
cd3 tcr1.340.7782351

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  • CD3 (immunology) - Wikipedia

    wikipedia.org

    https://en.wikipedia.org/wiki/CD3_(immunology)

    WebIn mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex.

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  • Mini-review: The T Cell Marker, CD3 Antigen and Antibodies

    bio-rad-antibodies.com

    https://www.bio-rad-antibodies.com/minireview-cd3-antibody.html

    WebThe CD3 complex serves as a T cell co-receptor that associates noncovalently with the T cell receptor (TCR) (Smith-Garvin et al. 2009). The CD3 protein complex is a defining feature of the T cell lineage, therefore anti-CD3 antibodies can be used effectively as T cell markers (Chetty and Gatter 1994).

    DA: 62 PA: 9 MOZ Rank: 54

  • Identifying and cloning the T cell receptor - Nature

    nature.com

    https://www.nature.com/articles/d42859-022-00041-6

    WebDec 6, 2022 · The TCR of conventional αβ T cells comprises highly variable α and β chains (which form the antigen-binding αβ heterodimer) and an invariant CD3 signalling complex, which is non-covalently...

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  • T-cell receptor - Wikipedia

    wikipedia.org

    https://en.wikipedia.org/wiki/T-cell_receptor

    WebThe two main subunits of TCR (α- and β-chains) are twisted together. CD3 and zeta subunits are required to carry out the signal transduction. The MHC-TCR-CD3 interaction for T cells is functionally similar to the antigen(Ag)-immunoglobulin(Ig)-FcR interaction for myeloid leukocytes, and Ag-Ig-CD79 interaction for B cells.

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  • CD3 | SpringerLink

    springer.com

    https://link.springer.com/referenceworkentry/10.1007/978-3-319-67199-4_507

    WebJan 1, 2018 · The three CD3 subunits CD3γ, CD3δ, and CD3ε form an integral part of the TCR complex and, together with CD3ζ, provide TCRαβ (and TCRγδ) with the signal transmission ability upon antigen binding. The CD3 proteins are type 1 TM proteins that form dimers, CD3εγ and CD3εδ, containing diverse cytoplasmic signaling motifs for inducible ...

    DA: 40 PA: 20 MOZ Rank: 19

  • Human TCR That Incorporate CD3ζ Induce Highly Preferred …

    aai.org

    https://journals.aai.org/jimmunol/article/180/11/7736/84666/Human-TCR-That-Incorporate-CD3-Induce-Highly

    WebJun 1, 2008 · Intracellular assembly and surface expression of TCR:CD3ζ chains is independent of endogenous CD3γ, δ, and ε. Taken together, our data support the use of TCRαβ:CD3ζ to prevent TCR mispairing, which may provide an adequate strategy to enhance efficacy and safety of TCR gene transfer.

    DA: 27 PA: 58 MOZ Rank: 7

  • Exploitation of CD3ζ to enhance TCR expression levels and …

    biorxiv.org

    https://www.biorxiv.org/content/10.1101/2024.02.14.580308v1.full.pdf

    WebFeb 14, 2024 · 98 Being a key component of TCR surface expression, CD3 is also crucial in TCR gene 99 therapy, where efficient TCR-CD3 assembly is required for optimal antigen-specific 100 function. We have previously shown that CD3 limits the TCR surface expression of 101 TCR gene engineered murine T cells.

    DA: 52 PA: 15 MOZ Rank: 43

  • Trispecific antibodies offer a third way forward for anticancer

    nature.com

    https://www.nature.com/articles/d41586-019-03495-3

    WebNov 18, 2019 · CD3 is part of the T-cell receptor (TCR), which recognizes abnormal cells by binding molecules called antigens. The binding of CD3 by the antibody drives T-cell activation (without...

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  • The physiological interactome of TCR-like antibody ... - Nature

    nature.com

    https://www.nature.com/articles/s41467-024-47062-5.pdf

    Webcomplex and monovalent binding to the CD3 ε chain of the TCR. This was facilitated by fusion of a second fragment antigen-binding region (Fab) to the N-terminus of the variable-light (VL) domain ...

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  • Pathology Outlines - CD3

    pathologyoutlines.com

    https://www.pathologyoutlines.com/topic/cdmarkerscd3.html

    WebMar 18, 2022 · Pathophysiology. CD3 is a cell surface complex composed of 4 distinct subunits; these subunits are chains of integral membrane glycoproteins that associate with T cell antigen receptor (TCR) and are required for TCR cell surface expression and signal transduction ( Immunity 2006;24:133, Nature 2019;573:546) Delta (CD3ƍ) ( OMIM: …

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