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What is the keynote-028 trial?

The KEYNOTE-028 trial is a single-arm, phase Ib basket trial that evaluated pembrolizumab in 20 cohorts of patients with a range of advanced solid tumors positive for programmed death ligand 1 (PD-L1). Exploratory study endpoints included the association between pembrolizumab efficacy and two inflammatory biomarkers and TMB.

Are ICIS effective in HER2+ advanced breast cancer?

Signals of clinical efficacy have been reported with the addition of ICIs to standard of care therapies in HER2+ advanced breast cancer.

Is adjuvant pembrolizumab included in keynote-522?

Although the experimental arm of KEYNOTE-522 included adjuvant pembrolizumab in addition to neoadjuvant chemotherapy and pembrolizumab, it is unclear whether or not the DFS benefit was derived from the neoadjuvant or adjuvant portions, or both.

Is leukocyte antigen expression associated with prognosis in advanced breast cancer?

Loss of human leukocyte antigen class I expression is associated with poor prognosis in patients with advanced breast cancer. J Pathol Transl Med2019;53:75–85. 10.4132/jptm.2018.10.11 [PMC free article][PubMed] [CrossRef] [Google Scholar] 278.


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