nature abe | Human cell based directed evolution of adenine base edito

Keyword	CPC	PCC	Volume	Score	Length of keyword
nature abe	2	0.6	3002	51	10
nature	1.3	0.4	9015	34	6
abe	1.04	0.4	889	37	3

Keyword	CPC	PCC	Volume	Score
nature abe	0.53	0.1	9625	96
nature abeille	0.12	0.4	1813	12
nature abenfruta	0.75	0.9	8841	52
nature abeille butineuse	0.99	0.6	6112	41
abe bailey nature reserve	1.38	0.2	6844	97

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Human cell based directed evolution of adenine base editors ... - Nature
nature.com

https://www.nature.com/articles/s41467-021-26211-0

WebOct 8, 2021 · Nature Communications - Application of adenine base editors (ABE) has been precluded by low activity. Here the authors show the generation of a human cell based ABE directional screening...

DA: 13 PA: 53 MOZ Rank: 85

Adenine base editor engineering reduces editing of bystander ... - Nature
nature.com

https://www.nature.com/articles/s41587-021-00943-2

WebJul 1, 2021 · Nature Biotechnology (2023) Adenine base editors (ABEs) catalyze specific A-to-G conversions at genomic sites of interest. However, ABEs also induce cytosine deamination at the target site.

DA: 64 PA: 40 MOZ Rank: 10

Structure-guided engineering of adenine base editor with …
nature.com

https://www.nature.com/articles/s41467-021-22519-z

WebApr 16, 2021 · Article 22 March 2024. Introduction. Adenine base editors (ABEs), which is originally designed by fusing a wild-type E.coli TadA (ecTadA) and a laboratory-evolved E.coli TadA (TadA*) with a Cas9...

DA: 96 PA: 31 MOZ Rank: 80

Evolution of an adenine base editor into a small, efficient ... - Nature
nature.com

https://www.nature.com/articles/s41587-022-01533-6

WebNov 10, 2022 · Nature Biotechnology 41 , 673–685 ( 2023) Cite this article. 30k Accesses. 46 Citations. 38 Altmetric. Metrics. Abstract. Cytosine base editors (CBEs) are larger and can suffer from higher...

DA: 95 PA: 10 MOZ Rank: 49

In vivo adenine base editing of PCSK9 in macaques reduces LDL ... - Nature
nature.com

https://www.nature.com/articles/s41587-021-00933-4

WebMay 19, 2021 · … Gerald Schwank. Show authors. Nature Biotechnology 39 , 949–957 ( 2021) Cite this article. 33k Accesses. 185 Citations. 302 Altmetric. Metrics. Abstract. Most known pathogenic point mutations...

DA: 15 PA: 82 MOZ Rank: 55

Hypercompact adenine base editors based on a Cas12f variant ... - Nature
nature.com

https://www.nature.com/articles/s41589-022-01077-5

WebAug 1, 2022 · Nature Chemical Biology - A hypercompact adenine base editor termed TaRGET-ABE was developed by fusing a catalytically inactive transposon-associated transposase B guided by an engineered RNA...

DA: 1 PA: 94 MOZ Rank: 65

Engineering a precise adenine base editor with minimal ... - Nature
nature.com

https://www.nature.com/articles/s41589-022-01163-8

WebOct 13, 2022 · Nature Chemical Biology - A precise adenine base editor variant, ABE9, was developed to generate single adenine transition at pathogenic homopolymeric adenine sites with minimal DNA/RNA...

DA: 81 PA: 37 MOZ Rank: 100

Programmable base editing of A•T to G•C in genomic DNA ... - Nature
nature.com

https://www.nature.com/articles/nature24644

WebNov 1, 2017 · Extensive directed evolution and protein engineering resulted in seventh-generation ABEs that convert targeted A•T base pairs efficiently to G•C (approximately 50% efficiency in human cells) with...

DA: 94 PA: 93 MOZ Rank: 23

In vivo CRISPR base editing of PCSK9 durably lowers ... - Nature
nature.com

https://www.nature.com/articles/s41586-021-03534-y

WebMay 19, 2021 · Here we report the efficient in vivo delivery of a CRISPR adenine base editor using lipid nanoparticles (LNPs) in cynomolgus monkeys to introduce a precise single-nucleotide PCSK9 loss-of-function...

DA: 72 PA: 7 MOZ Rank: 25

Engineering a precise adenine base editor with minimal bystander
nih.gov

https://pubmed.ncbi.nlm.nih.gov/36229683/

WebAdenine base editors (ABEs) catalyze A-to-G transitions showing broad applications, but their bystander mutations and off-target editing effects raise safety concerns. Through structure-guided engineering, we found ABE8e with an N108Q mutation reduced both adenine and cytosine bystander editing, and ….

DA: 47 PA: 12 MOZ Rank: 79